A new cytotoxic phenalenone derivative from Penicillium oxalicum

From the supernatant of the fermentation broth of Penicillium oxalicum, we isolated a previously undescribed peniciphenalenin G (1) and three known compounds 2-4. Their chemical structures were established through spectroscopic analysis as well as comparing with data in the literature. Compound 1 di...

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Bibliographic Details
Published inNatural Product Research Vol. 37; no. 8; pp. 1397 - 1400
Main Authors Qi, Xiaoying, Liu, Bing, Jiang, Zhongxiu
Format Report
LanguageEnglish
Published Taylor & Francis 18.04.2023
Subjects
colorectal cancer
marine fungus
Peniciphenalenin
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Summary:From the supernatant of the fermentation broth of Penicillium oxalicum, we isolated a previously undescribed peniciphenalenin G (1) and three known compounds 2-4. Their chemical structures were established through spectroscopic analysis as well as comparing with data in the literature. Compound 1 displayed a moderate cytotoxicity with IC 50 value 21.4 μM (positive drug regorafenib with IC 50 value of 8.2 μM) against Caco2 cells while compounds 2 and 3 showed weak cytotoxicities with IC 50 value of 52.1 and 39.2 μM, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.2008388