Cytotoxic activity of actinomycetes Nocardia sp. and Nocardiopsis sp. associated with marine sponge Amphimedon sp

Cancer is a hazard life-threatening disease, which affect huge population worldwide. Marine actinomycetes are considered as promising source for potential chemotherapeutic agents. In our study, we carried out metabolic profiling for Nocardia sp. UR 86 and Nocardiopsis sp. UR 92 that were cultivated...

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Bibliographic Details
Published inNatural Product Research Vol. 36; no. 11; pp. 2917 - 2922
Main Authors Shady, Nourhan Hisham, Tawfike, Ahmed F., Yahia, Ramadan, Fouad, Mostafa A., Brachmann, Alexander O., Piel, Jörn, Abdelmohsen, Usama Ramadan, Kamel, Mohamed Salah
Format Report
LanguageEnglish
Published Taylor & Francis 02.06.2022
Subjects
Amphimedon sp
cytotoxic
metabolic profiling
Nocardia sp
Nocardiopsis sp
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Summary:Cancer is a hazard life-threatening disease, which affect huge population worldwide. Marine actinomycetes are considered as promising source for potential chemotherapeutic agents. In our study, we carried out metabolic profiling for Nocardia sp. UR 86 and Nocardiopsis sp. UR 92 that were cultivated from the Red Sea sponge Amphimedon sp. to investigate their chemical diversity using different media conditions. The crude culture extracts were subjected to high-resolution mass spectrometry (HRMS) analysis. The chemical profiles of the different extracts of Nocardia sp. UR 86 and Nocardiopsis sp. UR 92 revealed their richness in diverse metabolites and consequently twenty compounds (1-20) were annotated. Moreover, the obtained extracts of the differently cultivated Nocardia sp. UR 86 and Nocardiopsis sp. UR 92 were investigated against three cell lines HepG2, MCF-7 and CACO2 and revealed the targeted cytotoxicity of Nocardia sp. and Nocardiopsis sp. metabolites against the three cell lines.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1931865