Botulinum toxin type A as an adjuvant treatment modality for extensive Hailey-Hailey disease

Background: Extensive Hailey-Hailey disease is often resistant to conventional topical and systemic therapies. The systemic and ablative therapies have many side effects and/or high recurrence rates. Therefore, an alternative safe and effective treatment is needed. Objective: To assess the effective...

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Bibliographic Details
Published inJournal of Dermatological Treatment Vol. 19; no. 4; pp. 251 - 254
Main Authors Koeyers, Wendy Jane, Van Der Geer, Simone, Krekels, Gertruud
Format Report
LanguageEnglish
Published Taylor & Francis 01.01.2008
Subjects
Benign familial pemphigus
botulinum toxin type A
BTXA
Hailey-Hailey disease
HH-disease
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Summary:Background: Extensive Hailey-Hailey disease is often resistant to conventional topical and systemic therapies. The systemic and ablative therapies have many side effects and/or high recurrence rates. Therefore, an alternative safe and effective treatment is needed. Objective: To assess the effectiveness of botulinum toxin type A in the treatment of extensive Hailey-Hailey disease. Methods: The cases of six patients with extensive Hailey-Hailey disease resistant to multiple therapeutic regimens were studied and described. Adjuvant therapy with botulinum toxin type A/Dysport ® was started in all six cases. Results: Marked improvement of the lesions was achieved with few side effects in all patients. Conclusion: Botulinum toxin type A is a safe and effective adjuvant treatment for extensive Hailey-Hailey disease.
ISSN:0954-6634
1471-1753
DOI:10.1080/09546630801955135