Coincidental occurance of episodic ataxia and multiple sclerosis: a case report and review of the literature

Episodic ataxia is a clinical condition characterized by episodes of balance and coordination problems that last minutes to hours. It can be inherited or sporadic, and it can be seen sporadically in epilepsy, basilar migraine, multiple sclerosis, vertebrobasilar ischaemia, and labyrinth diseases. In...

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Bibliographic Details
Published inInternational Journal of Neuroscience Vol. 132; no. 7; pp. 656 - 661
Main Authors Batum, Melike, Kısabay Ak, Ayşın, Çetin, Güldeniz, Çelebi, Hamide Betül Gerik, Çam, Sırrı, Mavioğlu, Hatice
Format Report
LanguageEnglish
Published Taylor & Francis 03.07.2022
Subjects
CACNA1A
episodic ataxia
genetic
heterozygous
Multiple sclerosis
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Summary:Episodic ataxia is a clinical condition characterized by episodes of balance and coordination problems that last minutes to hours. It can be inherited or sporadic, and it can be seen sporadically in epilepsy, basilar migraine, multiple sclerosis, vertebrobasilar ischaemia, and labyrinth diseases. In this article, we present a case of a patient who had a coincidental occurrence of episodic ataxia type 2 (EA2) and multiple sclerosis (MS) Results: The patient who had a previously unidentified heterozygous mutation in the calcium voltage-gated channel subunit alpha 1 A gene (CACNA1A). There is no publication in the literature reporting the co-occurrence of MS and EA2. This combination may be coincidental in this patient, or it may be a relationship that has not yet been scientifically revealed.
ISSN:0020-7454
1563-5279
DOI:10.1080/00207454.2020.1835896