Establishment of an Immunocompetent Nipple Valve Anastomosis to Prevent Faecal Reflux after Ileocolic Resection in Dogs
Objective: To construct an immunocompetent nipple valve anastomosis (NVA) to exclude faecal reflux and compare it with an end-to-end anastomosis to see if it would prevent recurrent inflammation caused by intraluminal bacterial antigens in Crohn's disease. Design: Laboratory study. Setting: Tea...
Saved in:
Published in | The European journal of surgery Vol. 166; no. 5; pp. 409 - 414 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Informa UK Ltd
2000
|
Online Access | Get full text |
Cover
Loading…
Summary: | Objective: To construct an immunocompetent nipple valve anastomosis (NVA) to exclude faecal reflux and compare it with an end-to-end anastomosis to see if it would prevent recurrent inflammation caused by intraluminal bacterial antigens in Crohn's disease. Design: Laboratory study. Setting: Teaching hospital, Germany. Animals: Two groups of six beagle dogs each of which had NVA or end-to-end anastomosis. Interventions: Construction of a NVA by stapling the telescoped nipple, and replacing the ileal mucosa on the valve by colonic mucosa; end-to-end anastomosis. Main outcome measures: Radiological, bacteriological, angiographic, and morphometric results. Results: Absolute retrograde pressure-competence and free orthograde permeability of the NVA resulted in significantly lower intestinal bacterial counts compared with the end-to-end anastomosis (p < 0.05). Transposition of colonic mucosa was successful as demonstrated by revascularisation from the ileal nipple and looked normal on morphometry. Conclusion: If NVA were constructed in patients with Crohn's disease, recurrences should be prevented, which would verify the immunopathogenetic hypothesis of new inflammation. |
---|---|
ISSN: | 1102-4151 1741-9271 |
DOI: | 10.3109/110241500750008998 |