Simulation of Parkinsonian Globus Pallidus Nuclei with various network motifs

Parkinson's disease is a neurodegenerative disorder that affect human life quite negatively with motor, cognitive and psychiatric way. Recent electrophysiological experiments have shown that Basal Ganglia, spaced in the midbrain, can lead to Parkinsonism. Beta frequency oscillations and irregul...

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Bibliographic Details
Published in2017 Medical Technologies National Congress (TIPTEKNO) pp. 1 - 4
Main Authors Calim, Ali, Ozer, Mahmut, Uzuntarla, Muhammet
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.10.2017
Subjects
Basal ganglia
Biological system modeling
bursting
Computational modeling
globus pallidus
Mathematical model
network motifs
Oscillators
parkinson
Parkinson's disease
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Summary:Parkinson's disease is a neurodegenerative disorder that affect human life quite negatively with motor, cognitive and psychiatric way. Recent electrophysiological experiments have shown that Basal Ganglia, spaced in the midbrain, can lead to Parkinsonism. Beta frequency oscillations and irregular burstings are most important symptoms of Parkinson's disease. They appear in Globus Pallidus and Subtalamus nuclei during the disease. In this study, anatomical connection features that may give rise to emergence of burstings are investigated, simulating Globus Pallidus and Subtalamus nuclei numerically.
DOI:10.1109/TIPTEKNO.2017.8238106