Optogentics and optrode technology to brain function manupulation

Optogenetics comprises a growing family of related techniques for the optical interrogation and control of excitable cells. Combining genetic targeting with light delivery systems makes it possible to drive or silence subpopulations of neurons and the related behaviours, with a high spatiotemporal p...

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Bibliographic Details
Published in2016 4th International Conference on Photonics, Optics and Laser Technology (PHOTOPTICS) pp. 1 - 12
Main Authors Zibaii, Mohammad Ismail, Dargahi, Leila, Ronaghi, Abdolaziz, Abedzadeh, Farshad, Pandamoz, Sareh, Salehi, Saeid, Fattahi, Zahra, Haghparast, Abbas, Latifi, Hamid
Format Conference Proceeding
LanguageEnglish
Published SCITEPRESS 01.02.2016
Subjects
Channelrhodopsin
Fiber Optic
Lighting
Neural Recording
Neurons
Optical fibers
Optical recording
Optical Stimulation
Optogenetics
Optrode
Sociology
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Summary:Optogenetics comprises a growing family of related techniques for the optical interrogation and control of excitable cells. Combining genetic targeting with light delivery systems makes it possible to drive or silence subpopulations of neurons and the related behaviours, with a high spatiotemporal precision. Since optical manipulation is fast, selective, and minimally invasive, it provides distinct advantages over traditional electrical means or pharmacological approaches for cell perturbation. Here we showed in anesthetized rat that optogenetic stimulation of nucleus accumbens (NAc) neurons increased neural activation. We labelled a population of neurons activated with channelrhodopsin-2 (ChR2) and later optically stimulated these neurons by using an optrode and recorded spontaneous action potentials from the one neuron.