Effects of patchy dispersion of the coupling resistance and refractoriness on cardiac reentries

This study aimed at finding preponderant factors able to provoke cardiac reentries linked to ischemia. Numerical simulations of a sheet of ventricular wall were based on the van Capelle and Durrer model and performed on a 128/spl times/128 array. They showed that alteration of (1) action potential d...

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Bibliographic Details
Published inProceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136) Vol. 1; pp. 19 - 20 vol.1
Main Authors Seigneuric, R.G., Chasse, J.-L., Auger, P.M., Bardou, A.L.
Format Conference Proceeding
LanguageEnglish
Published IEEE 1997
Subjects
Dispersion
Fibrillation
Frequency
Heart
Ischemic pain
Numerical simulation
Pathology
Rhythm
Senior members
Spirals
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Summary:This study aimed at finding preponderant factors able to provoke cardiac reentries linked to ischemia. Numerical simulations of a sheet of ventricular wall were based on the van Capelle and Durrer model and performed on a 128/spl times/128 array. They showed that alteration of (1) action potential duration and (2) action potential duration and coupling resistance did not lead to pathological patterns with a cell by cell dispersion. In the contrary, when a patchy dispersion was envisaged, double-limb reentries could occur under peculiar conditions. To do so, a sufficient patch size was necessary (critical size) for both (1) and (2). Moreover, the probability of reentry was an increasing function of the number of ischemic patches. Some of these functionally reentrant patterns can be related to polymorphic tachycardia.
ISBN:9780780342620
0780342623
ISSN:1094-687X
1558-4615
DOI:10.1109/IEMBS.1997.754451