Mathematical model of glucose-insulin metabolism from carbohydrates in type 1 diabetes during postprandial and postabsorptive states
In this paper, we propose an extension to our previously developed mathematical model of glucose-insulin metabolism in type 1 diabetes (T1D). It comprises a carbohydrate metabolism subsystem with a solid foundation of the relative impact of carbohydrates on blood glucose levels; an exogenous insulin...
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Published in | The SICE Annual Conference 2013 pp. 170 - 175 |
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Main Authors | , , |
Format | Conference Proceeding |
Language | English |
Published |
The Society of Instrument and Control Engineers - SICE
01.09.2013
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Subjects | |
Online Access | Get full text |
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Summary: | In this paper, we propose an extension to our previously developed mathematical model of glucose-insulin metabolism in type 1 diabetes (T1D). It comprises a carbohydrate metabolism subsystem with a solid foundation of the relative impact of carbohydrates on blood glucose levels; an exogenous insulin subsystem that considers the effect of subcutaneous and intravenous rapid-acting insulin; and a glucose-insulin metabolism subsystem in T1D for postprandial and postabsorptive states. Simulations of blood glucose excursion in our model during both states demonstrate the reliability and accuracy of our model. |
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