Mathematical model of glucose-insulin metabolism from carbohydrates in type 1 diabetes during postprandial and postabsorptive states

In this paper, we propose an extension to our previously developed mathematical model of glucose-insulin metabolism in type 1 diabetes (T1D). It comprises a carbohydrate metabolism subsystem with a solid foundation of the relative impact of carbohydrates on blood glucose levels; an exogenous insulin...

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Bibliographic Details
Published inThe SICE Annual Conference 2013 pp. 170 - 175
Main Authors Yamamoto Noguchi, Claudia Cecilia, Furutani, Eiko, Sumi, Shoichiro
Format Conference Proceeding
LanguageEnglish
Published The Society of Instrument and Control Engineers - SICE 01.09.2013
Subjects
Absorption
Biochemistry
Blood
carbohydrate metabolism
Data models
glucose-insulin metabolism
glycemic index
Insulin
Mathematical model
mathematical modeling
rapidly-absorbed glucose
slowly-absorbed glucose
Sugar
type 1 diabetes
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Summary:In this paper, we propose an extension to our previously developed mathematical model of glucose-insulin metabolism in type 1 diabetes (T1D). It comprises a carbohydrate metabolism subsystem with a solid foundation of the relative impact of carbohydrates on blood glucose levels; an exogenous insulin subsystem that considers the effect of subcutaneous and intravenous rapid-acting insulin; and a glucose-insulin metabolism subsystem in T1D for postprandial and postabsorptive states. Simulations of blood glucose excursion in our model during both states demonstrate the reliability and accuracy of our model.