1E-2 Experimental Characterization of Ferucarbotran (Resovist ®) as a Photoacoustic Nanoparticle Contrast Agent

Photoacoustics (PA) combines the high contrast of optical imaging modalities with the high resolution of clinical ultrasound. Photoacoustic contrast agents improve the maximum imaging depth of photoacoustic imaging and may render it possible to use this modality for molecular imaging. Organic dyes,...

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Bibliographic Details
Published in2006 IEEE Ultrasonics Symposium pp. 393 - 396
Main Authors Mienkina, M.P., Hensel, K., Le, T.N., Gerhardt, N.C., Hansen, C., Hofmann, M., Schmitz, G.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.10.2006
Subjects
Gold
High-resolution imaging
Image resolution
Imaging phantoms
Iron
Molecular imaging
Nanoparticles
Optical imaging
Toxicology
Ultrasonic imaging
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Summary:Photoacoustics (PA) combines the high contrast of optical imaging modalities with the high resolution of clinical ultrasound. Photoacoustic contrast agents improve the maximum imaging depth of photoacoustic imaging and may render it possible to use this modality for molecular imaging. Organic dyes, like indocyanine green, or inorganic nanoparticles are used as photoacoustic contrast agents. However, the toxicological properties of many nanoparticles, like gold, have still not been fully investigated. Therefore, in this paper the photoacoustic properties of Ferucarbotran are investigated. Ferucarbotran is a clinically established contrast agent for magnetic resonance imaging. It consists of superparamagnetic iron oxide nanoparticle cores coated with carboxydextran. In order to evaluate the photoacoustic application of Ferucarbotran, gelatin phantoms with different Ferucarbotran concentrations were fabricated. These phantoms, which were mounted on a three-dimensional positioning system, were irradiated by a Nd:YAG laser (1064 nm) and the photoacoustic signals were acquired by a single element ultrasound transducer (7.5 MHz). The experiments showed that in order to achieve a 6 dB gain of photoacoustic received signal energy compared to signals from gelatin a Ferucarbotran concentration of 1.9 mumol Fe/ml is needed. This concentration is equivalent to the quadruple in vivo concentration of Ferucarbotran in the human liver
ISBN:9781424402014
1424402018
ISSN:1051-0117
DOI:10.1109/ULTSYM.2006.111