A grid-based stochastic simulation of unitary and membrane Ca/sup 2+/ currents in spherical cells

We present a stochastic simulation of L-type Ca/sup 2+/ current assuming thousands of calcium channels on the membrane of a spherical cell. We propose a three-state Markov model to simulate the individual contribution of each channel. Rather than using a statistical approximation, we actually consid...

Full description

Saved in:
Bibliographic Details
Published in18th IEEE Symposium on Computer-Based Medical Systems (CBMS'05) pp. 171 - 176
Main Authors Gonzalez-Velez, V., Gonzalez-Velez, H.
Format Conference Proceeding
LanguageEnglish
Published IEEE 2005
Subjects
Biomembranes
Calcium
Cells (biology)
Chemistry
Computational modeling
Current measurement
Heart
Predictive models
Stochastic processes
Voltage
Online AccessGet full text

Cover

More Information
Summary:We present a stochastic simulation of L-type Ca/sup 2+/ current assuming thousands of calcium channels on the membrane of a spherical cell. We propose a three-state Markov model to simulate the individual contribution of each channel. Rather than using a statistical approximation, we actually consider each individual channel transitions between states and evaluate the unitary channel current. We compare this aggregated unitary contributions with simulated whole cell currents, both in response to a depolarising voltage pulse. On the computational side, we have employed a parameter-sweep, component based approach. Being embarrassingly parallel by design, we have parallelised it in a naive manner. We argue its possible extension using algorithmic skeletons. The results presented account for hours of processing time on a dedicated grid.
ISBN:0769523552
9780769523552
ISSN:1063-7125
DOI:10.1109/CBMS.2005.10