Microdevices for biomolecular detection

Summary form only given. Our research focuses on using silicon microfabrication to develop quantitative, high throughput and realtime techniques for measuring biomolecular interactions. Over the last year, we have developed a new detection method where specific biomolecules adsorb to the walls of a...

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Published inThe 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2; p. 5395 Vol.7
Main Author Manalis, S.R.
Format Conference Proceeding
LanguageEnglish
Published IEEE 2004
Subjects
BioMEMS
Damping
Drag
Electrostatic measurements
Microchannel
microfluid
Microfluidics
Molecular biophysics
Resonant frequency
sensor
Silicon
Systems biology
Throughput
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Summary:Summary form only given. Our research focuses on using silicon microfabrication to develop quantitative, high throughput and realtime techniques for measuring biomolecular interactions. Over the last year, we have developed a new detection method where specific biomolecules adsorb to the walls of a suspended microchannel resonator and thereby lower its resonant frequency. Confining the fluid to the inside of the resonator significantly increases sensitivity by eliminating high damping and viscous drag. It also enables direct integration with conventional microfluidic systems and allows the resonator to be actuated by electrostatic forces. In this presentation, I will introduce the resonator, show recent progress towards achieving its fundamental limit of detection, and outline a path towards high throughput measurement for systems biology.
ISBN:0780384393
9780780384392
DOI:10.1109/IEMBS.2004.1404508