A 128 /spl times/ 128 CMOS bio-sensor array for extracellular recording of neural activity

A CMOS sensor array for monitoring neural signals of living cells with 128 /spl times/ 128 pixels in a 1 mm/sup 2/ area is described. A standard 0.5 /spl mu/m, 5 V CMOS process extended by top electrodes covered by a relatively thin bio-compatible dielectric is used. Detection circuitry is based on...

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Published in2003 IEEE International Solid-State Circuits Conference, 2003. Digest of Technical Papers. ISSCC pp. 222 - 489 vol.1
Main Authors Eversmann, B., Jenkner, M., Paulus, C., Hofmann, F., Brederlow, R., Holzapfl, B., Fromherz, P., Brenner, M., Schreiter, M., Gabl, R., Plehnert, K., Steinhauser, M., Eckstein, G., Schmitt-Landsiedel, D., Thewes, R.
Format Conference Proceeding
LanguageEnglish
Published IEEE 2003
Subjects
Biomembranes
Biosensors
Cells (biology)
CMOS process
Dielectrics
Electrodes
Extracellular
MOSFET circuits
Sensor arrays
Voltage
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Summary:A CMOS sensor array for monitoring neural signals of living cells with 128 /spl times/ 128 pixels in a 1 mm/sup 2/ area is described. A standard 0.5 /spl mu/m, 5 V CMOS process extended by top electrodes covered by a relatively thin bio-compatible dielectric is used. Detection circuitry is based on a sensor-MOSFET mismatch-compensating current-mode technique.
ISBN:0780377079
9780780377073
ISSN:0193-6530
2376-8606
DOI:10.1109/ISSCC.2003.1234276