Human housekeeping genes interrogated with Gini-index and GTEx datasets

Housekeeping genes are stably expressed genes that are essential for molecular and systems biology studies. We used Gini index profiles to discover housekeeping genes in human subjects, in addition to major tissue subtypes. We investigated tissue-specific housekeeping genes using GTEx datasets from...

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Bibliographic Details
Published inProceedings (IEEE International Conference on Bioinformatics and Biomedicine) pp. 7089 - 7091
Main Author Lin, Wen-Chang
Format Conference Proceeding
LanguageEnglish
Published IEEE 03.12.2024
Subjects
Bioinformatics
Biological systems
Gini index
GTEx
housekeeping genes
Indexes
Protein engineering
protein-coding genes
Proteins
sexual dimorphism
Systems biology
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ISSN2156-1133
DOI10.1109/BIBM62325.2024.10822433

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Summary:Housekeeping genes are stably expressed genes that are essential for molecular and systems biology studies. We used Gini index profiles to discover housekeeping genes in human subjects, in addition to major tissue subtypes. We investigated tissue-specific housekeeping genes using GTEx datasets from over 16,000 normal tissue samples. As a result, we identified 529 housekeeping genes that are conserved across 27 major organs. The expression variations of these housekeeping genes were then compared between male and female participants for further sexual dimorphism studies. This research suggests alternate sets of human housekeeping protein-coding genes that exhibit more consistent expression profiles.
ISSN:2156-1133
DOI:10.1109/BIBM62325.2024.10822433