Logic-Gate-Controlled Density of Antibody Binding Sites on Sensing Surface for Immunoassays with Improved Analytical Performance

This study addresses the challenge of balancing analytical performance (e.g., sensitivity, specificity, dynamic range) in the biosensing systems. Introducing a universal approach, we propose a surface with a molecularly controlled density of antibody binding sites using the molecular logic gate. Emp...

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Bibliographic Details
Published in2024 International Conference Laser Optics (ICLO) p. 548
Main Authors Belyakov, N.A., Novichikhin, D.O., Gorshkov, B.G.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.07.2024
Subjects
analytical performance
antibiotics detection
Antibodies
antibody binding sites
Dynamic range
interferometry
Logic gates
molecular logic gate
optical biosensing
Optical interferometry
Quality control
Sensitivity
sensor chips
Surface emitting lasers
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Summary:This study addresses the challenge of balancing analytical performance (e.g., sensitivity, specificity, dynamic range) in the biosensing systems. Introducing a universal approach, we propose a surface with a molecularly controlled density of antibody binding sites using the molecular logic gate. Employing spectral interferometry, the ability to detect antibiotic chloramphenicol using glass sensor chips with adjustable density of biosensitive elements was experimentally demonstrated. This innovative approach offers controlled analytical characteristics for developing advanced systems to detect low-molecular-weight substances in areas such as food quality control, in vitro diagnostics, and veterinary medicine.
ISSN:2642-5580
DOI:10.1109/ICLO59702.2024.10624263