Measuring, modeling and manipulating cell communication in Drosophila egg development

We report a model-based analysis of a recently proposed mechanism in Drosophila oogenesis (Peri et al., 1999; Sapir et al., 1998; Wasserman and Freeman, 1998). Our model describes the spatial organization and the dynamics of autocrine and paracrine signaling through the Drosophila Epidermal Growth F...

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Bibliographic Details
Published inProceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology Vol. 3; pp. 2200 - 2201 vol.3
Main Authors Shvartsman, S.Y., Muratov, C.B.
Format Conference Proceeding
LanguageEnglish
Published IEEE 2002
Subjects
Amino acids
Embryo
Epidermis
Feedback loop
Genetics
Inhibitors
Pattern analysis
Predictive models
Proteins
Signal analysis
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Summary:We report a model-based analysis of a recently proposed mechanism in Drosophila oogenesis (Peri et al., 1999; Sapir et al., 1998; Wasserman and Freeman, 1998). Our model describes the spatial organization and the dynamics of autocrine and paracrine signaling through the Drosophila Epidermal Growth Factor Receptor (EGFR) (Casci and Freeman, 1999; Nilson and Schupbach, 1999; Perrimon and Perkins, 1997; Schweitzer and Shilo, 1997). We use the model to estimate the relative spatial ranges and time scales of the relevant feedback loops, to interpret the phenotypic transitions in eggshell morphology, and to predict the effects of new genetic manipulations.
ISBN:0780376129
9780780376120
ISSN:1094-687X
1558-4615
DOI:10.1109/IEMBS.2002.1053239