Seropill: Novel Minimally Invasive Ingestible Capsule for Serotonin Sensing in the GI Tract

This paper reports the first serotonin (5-HT) sensing ingestible capsule allowing minimally invasive real-time in vivo detection of luminally released serotonin in the gastrointestinal (GI) tract. The system utilizes a surface-mounted sensor with an Au-carbon nanotube (CNT) working electrode, Au cou...

Full description

Saved in:
Bibliographic Details
Published in2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) pp. 1884 - 1887
Main Authors Straker, Michael A., Levy, Joshua A., Stine, Justin M., Han, Jinjing, Beardslee, Luke A., Ghodssi, Reza
Format Conference Proceeding
LanguageEnglish
Published IEEJ 25.06.2023
Subjects
Electrodes
In vivo
Ingestible Capsule
Ingestible Electronics
Microbiome
Minimally invasive surgery
Sensing
Sensitivity
Serotonin
Transducers
Wireless communication
Wireless Sensing
Wireless sensor networks
Online AccessGet full text

Cover

More Information
Summary:This paper reports the first serotonin (5-HT) sensing ingestible capsule allowing minimally invasive real-time in vivo detection of luminally released serotonin in the gastrointestinal (GI) tract. The system utilizes a surface-mounted sensor with an Au-carbon nanotube (CNT) working electrode, Au counter electrode, and Ag/AgCl reference electrode. The capsule uses previously reported electronics packaged in a 3D-printed ASA shell to perform cyclic voltammetry, allowing the detection and quantification of local serotonin concentration with a dynamic range of 2-10 µM. This device marks a step toward wireless ingestible systems for real-time evaluation of gastrointestinal microbiome metabolites in vivo.
ISSN:2167-0021