A Comparison Of The Effectiveness Of The Sodium Phosphate And Sennosides Used In Preparation For Colonoscopy

• Published in: Cerrahi sanatlar dergisi Vol. 9; no. 1
• Main Authors: Yıldar,Murat, Başbug,Murat, Çavdar,Faruk, Derici,Hayrullah, Yaman,İsmail
• Format: Journal Article
• Language: English
• Published: Cerrahi Sanatlar Dergisi 01.01.2016
• Subjects: Sağlık Hizmetleri; Tıp; İzmir; Türkiye; sodyum fosfat ve sennosid; sodium phosphate; Kolonoskopi hazırlığı; Colonoscopy preperation; and sennoside
• ISSN: 1308-0709

Polyethylene glycol (PEG) and sodium phosphate (NaP) are routinely used for colonoscopy preparation (CP). However, PEG’s high volume and the fact that NaP can cause electrolyte anomalies and renal toxicity limit the use of these in high risk patient groups. Sennosides, which are not commonly used exclusively for CP, are better tolerated but are thought to provide inadequate cleansing and are therefore generally employed additional-ly to a PEG regimen. The exclusive use of sennosides for CP is controversial. This study compared the effects of NaP and sennosides in CP. Patients undergoing colonoscopy and admitted to the colonoscopy unit from June 2013 to August 2014 were investigated retrospectively. Patients using NaP and sennoside in the cleansing protocol were compared on the basis of the cleansing regimen used in terms of age, sex, body mass index (BMI), potential complications during preparation such as nausea, vomiting, abdominal pain, headache and dizziness, time to reach the cecum, total duration of colonoscopy, rate of polyp determination and colonic cleanliness based on the Boston Bowel Preparation Scale (BPPS). Forty (46.0%) of the 87 patients were male and 47 (54.0%) were female. Mean age was 53.7±12.0 and mean BMI was 28.5±4.4. No significant difference was determined between the groups in terms of sex, age or BMI. Right colon BPPS score was significantly higher in the NaP group than in the sennoside group (2.4±0.6 and 2.1±0.8, respectively). This elevation did not significantly affect the rates of polyp detection between the groups. Significantly more nausea, vomiting, dizziness and headache were seen in the NaP group. NaP has a higher incidence of side-effects but provides more effective cleansing in the cecum and de-scending colon compared to sennosides, although this does not significantly affect the rate of polyp detection. We therefore suggest that the better-tolerated sennosides can be used as an alternative to NaP in routine prepara-tion for colonoscopy.