Frontal Plane QRS-T Angle as a Marker of Cardiac Iron Overload in Patients with Beta Thalassemia Major

Introduction: Cardiomyopathy due to myocardial iron deposition is the leading cause of death in transfusion-dependent beta-thalassemia major (β-TM) patients. Although cardiac T2* magnetic resonance imaging (MRI) can be used for the early detection of cardiac iron level before the onset of symptoms a...

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Published inActa Cardiologica Sinica Vol. 39; no. 3; pp. 406 - 415
Main Authors Görkem Kuş, Göksel Çağırcı, Nermin Bayar, Edip Can Özgünoğlu, Çağın Mustafa Üreyen, Ramazan Güven, Erdal Kurtoğlu, Şakir Arslan
Format Journal Article
LanguageChinese
Published 台灣 中華民國心臟學會 01.05.2023
Subjects
Beta-thalassemia major
Cardiac MR imaging
Electrocardiography
Frontal QRS-T angle
MEDLINE
SCIE
Scopus
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Summary:Introduction: Cardiomyopathy due to myocardial iron deposition is the leading cause of death in transfusion-dependent beta-thalassemia major (β-TM) patients. Although cardiac T2* magnetic resonance imaging (MRI) can be used for the early detection of cardiac iron level before the onset of symptoms associated with iron overload, this expensive method is not widely available in many hospitals. Frontal QRS-T angle is a novel marker of myocardial repolarization and is associated with adverse cardiac outcomes. We aimed to investigate the relationship between cardiac iron load and f(QRS-T) angle in patients with β-TM. Methods: The study included 95 β-TM patients. Cardiac T2* values under 20 were considered to indicate cardiac iron overload. The patients were divided into two groups according to the presence or absence of cardiac involvement. Laboratory and electrocardiography parameters, including frontal plane QRS-T angle, were compared between the two groups. Results: Cardiac involvement was detected in 33 (34%)
ISSN:1011-6842