芸香?與槲皮素於鼠體內之生可用率及代謝動力學

Rutin and quercetin, a flavone glycoside and its aglycone, are the flavonoids most widely and abundantly present in herbs and plant foods. The aim of this study was to characterize and compare the bioavailability and metabolic pharmacokinetics of rutin and quercetin in rats. Quercetin was administer...

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Published in藥物食品分析 Vol. 13; no. 3; pp. 244 - 250
Main Authors 楊啟裕(Yang, Chi-yu), 徐素蘭(Hsiu, Su-lan), 溫國慶(Wen, Kuo-ching), 林宣霈(Lin, Shiuan-pey), 蔡尚元(Tsai, Shang-yuan), 侯鈺琪(Hou, Yu-chi), 李珮端(Lee Chao, Pei-dawn)
Format Journal Article
LanguageChinese
Published 台灣 衛生福利部食品藥物管理署 01.09.2005
Subjects
Conjugated metabolites
Glucuronides
MEDLINE
Pharmacokinetics
Quercetin
Rutin
SCIE
Scopus
Sulfates
槲皮素
結合態代謝物
芸香?
藥物動力學
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Summary:Rutin and quercetin, a flavone glycoside and its aglycone, are the flavonoids most widely and abundantly present in herbs and plant foods. The aim of this study was to characterize and compare the bioavailability and metabolic pharmacokinetics of rutin and quercetin in rats. Quercetin was administered intravenously (33 μmol/kg) and orally 165 μmol/kg), while rutin was administered only orally (328 μmol/kg) to rats. Blood samples were withdrawn via cardiopuncture at specific time points. An HPLC method was used to determine the concentrations of quercetin before and after hydrolysis using β-glucuronidase and sulfatase, respectively. The pharmacokinetic parameters were calculated using noncompartment model of WINNONLIN. The results showed that after intravenous administration of quercetin, 93.8% of the dose was circulating as its sulfates and glucuronides. After oral administration of quercetin, the glucuronides and sulfates of quercetin were exclusively present in the bloodstream, whereas the parent form of qu
ISSN:1021-9498