Mural Inflammation in Crohn Disease: Location-Matched Histologic Validation of MR Imaging Features1
Purpose: To validate proposed magnetic resonance (MR) imaging features of Crohn disease activity against a histopathologic reference. Materials and Methods: Ethical permission was given by the University College London hospital ethics committee, and informed written consent was obtained from all par...
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Published in | Radiology Vol. 252; no. 3; p. 712 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Radiological Society of North America
01.09.2009
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Online Access | Get full text |
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Summary: | Purpose: To validate proposed magnetic resonance (MR) imaging features of Crohn disease activity against a histopathologic reference.
Materials and Methods: Ethical permission was given by the University College London hospital ethics committee, and informed written consent was
obtained from all participants. Preoperative MR imaging was performed in 18 consecutive patients with Crohn disease undergoing
elective small-bowel resection. The Harvey-Bradshaw index, the C-reactive protein level, and disease chronicity were recorded.
The resected bowel was retrospectively identified at preoperative MR imaging, and wall thickness, mural and lymph node/cerebrospinal
fluid (CSF) signal intensity ratios on T2-weighted fat-saturated images, gadolinium-based contrast material uptake, enhancement
pattern, and mesenteric signal intensity on T2-weighted fat-saturated images were recorded. Precise histologic matching was
achieved by imaging the ex vivo surgical specimens. Histopathologic grading of acute inflammation with the acute inflammatory
score (AIS) (on the basis of mucosal ulceration, edema, and quantity and depth of neutrophilic infiltration) and the degree
of fibrostenosis was performed at each site, and results were compared with MR imaging features. Data were analyzed by using
linear regression with robust standard errors of the estimate.
Results: AIS was positively correlated with mural thickness and mural/CSF signal intensity ratio on T2-weighted fat-saturated images
( P < .001 and P = .003, respectively) but not with mural enhancement at 30 and 70 seconds ( P = .50 and P = .73, respectively). AIS was higher with layered mural enhancement ( P < .001), a pattern also commonly associated with coexisting fibrostenosis (75%). Mural/CSF signal intensity ratio on T2-weighted
fat-saturated images was higher in histologically edematous bowel than in nonedematous bowel ( P = .04). There was no correlation between any lymph node characteristic and AIS.
Conclusion: Increasing mural thickness, high mural signal intensity on T2-weighted fat-saturated images, and a layered pattern of enhancement
reflect histologic features of acute small-bowel inflammation in Crohn disease.
Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/radiol.2523082167/DC1
© RSNA, 2009 |
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ISSN: | 0033-8419 1527-1315 |
DOI: | 10.1148/radiol.2523082167 |