Hypoxia-Inducible Factor 1α Polymorphism and Coronary Collaterals in Patients With Ischemic Heart Disease
Study objectives: Marked variability exists in coronary artery collaterals in patients with ischemic heart disease. Although multiple factors are thought to play a role in collateral development, the contribution of genetic factors is largely unknown. Hypoxia inducible factor 1 (HIF-1), a transcript...
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Published in | Chest Vol. 128; no. 2; p. 787 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
American College of Chest Physicians
01.08.2005
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Online Access | Get full text |
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Summary: | Study objectives: Marked variability exists in coronary artery collaterals in patients with ischemic heart disease. Although multiple factors
are thought to play a role in collateral development, the contribution of genetic factors is largely unknown. Hypoxia inducible
factor 1 (HIF-1), a transcriptional activator that functions as a master regulator of oxygen homeostasis, is one possible
genetic factor that could play an important role in modulating collateral development.
Design, setting, and participants: Collateral vessels were determined in 100 patients with ⥠70% narrowing of at least one coronary artery without acute myocardial
infarction or prior revascularization. DNA was genotyped for the presence of a single nucleotide (C to T) polymorphism that
changes residue 582 of HIF-1α from proline to serine.
Measurements and results: The frequency of the T allele was significantly higher among patients without collaterals compared to patients with collaterals
(0.188 vs 0.037, p < 0.001). In multivariate analyses, two variables affecting collateral formation were detected: two- or
three-vessel coronary artery disease was a significant positive predictor (odds ratio [OR], 4.17; 95% confidence interval
[CI], 1.61 to 10.8; p = 0.001), whereas the presence of HIF-1α genotype CT or TT was a negative predictor (OR, 0.19; 95% CI,
0.04 to 0.84; p = 0.03).
Conclusions: These data suggest that variations in HIF-1α genotype may influence development of coronary artery collaterals in patients
with significant coronary artery disease. |
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ISSN: | 0012-3692 1931-3543 |
DOI: | 10.1378/chest.128.2.787 |