Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus PrPC AND T CELL DIFFERENTIATION

Cellular prion protein (PrP(C)) is an ubiquitously expressed glycoprotein whose roles are still widely discussed, particularly in the field of immunology. Using TgA20- and Tg33-transgenic mice overexpressing PrP(C), we investigated the consequences of this overexpression on T cell development. In bo...

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Published inThe Journal of immunology (1950) Vol. 176; no. 6; pp. 3490 - 7
Main Authors Jouvin-Marche, Evelyne, Attuil-Audenis, Valérie, Aude-Garcia, Catherine, Rachidi, Walid, Zabel, Mark, Podevin-Dimster, Valérie, Siret, Carole, Huber, Christoph, Martinic, Marianne, Riondel, Jacqueline, Villiers, Christian L., Favier, Alain, Naquet, Philippe, Cesbron, Jean-Yves, Marche, Patrice N.
Format Journal Article
LanguageEnglish
Published Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists 15.03.2006
Subjects
Animals
Antigens, CD
Antioxidants
Cell Differentiation
Copper
Dietary Supplements
Gene Expression Regulation
Immunology
Life Sciences
Mice
Mice, Inbred C57BL
Mice, Transgenic
Phenotype
Prions
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
Thymus Gland
Oxydative Stress
Prion
T lymphocyte
Thymus
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Summary:Cellular prion protein (PrP(C)) is an ubiquitously expressed glycoprotein whose roles are still widely discussed, particularly in the field of immunology. Using TgA20- and Tg33-transgenic mice overexpressing PrP(C), we investigated the consequences of this overexpression on T cell development. In both models, overexpression of PrP(C) induces strong alterations at different steps of T cell maturation. On TgA20 mice, we observed that these alterations are cell autonomous and lead to a decrease of alphabeta T cells and a concomitant increase of gammadelta T cell numbers. PrP(C) has been shown to bind and chelate copper and, interestingly, under a copper supplementation diet, TgA20 mice presented a partial restoration of the alphabeta T cell development, suggesting that PrP(C) overexpression, by chelating copper, generates an antioxidant context differentially impacting on alphabeta and gammadelta T cell lineage.
ISSN:0022-1767
1550-6606