In vitro and in vivo efficacity of the Active Oligo Skin complex™, a new active ingredient processed from sea water, on multiple parameters of atopic skins

• Published in: Skin health and disease
• Main Authors: Lebonvallet, Nicolas, Catovic, Chloé, Feuilloley, Marc, Leschiera, Raphael, Reux, Alexia, Talagas, Matthieu, Cousin, Ianis, Misery, Laurent, Simon, Emilie, Chopin, Sylvie, Gardères, Johan
• Format: Journal Article
• Language: English
• Published: Wiley 14.02.2025
• Subjects: Life Sciences
• ISSN: 2690-442X; 2690-442X
• DOI: 10.1093/skinhd/vzae029

Abstract Background Different symptoms are associated with atopic skin (AS), including dryness, pruritus and pain, impacting patients’ quality of life. The environment, microbiota, epidermis, immune and nerve cells are all implicated in the pathogenesis of atopic skin. Staphylococcus aureus is the focus of particular attention. Epidermis is implicated at multiple levels: inflammatory process, barrier, control of moisture and water loss. Sensory neurons that participate in cutaneous neurogenic inflammation and pruritus are seen as a potential new target. Specific management strategies, and future therapies for adults and children are needed to help in more refractory cases. As a baseline of management, guidelines recommend a therapy to moisturize the skin and maintain the skin barrier function, such as emollient. Objectives The objective of this work is to evaluate a new product in vitro and in vivo in order to validate the potential of its use to people with atopic skin or dry skin. Methods A specific mineral composition, Active Oligo Skin complex™, from sea water was developed and included in a balm. The effects of solution and balm containing the complex were evaluated in vitro on bacteria growth and biofilm formation of Staphylococcus aureus and Staphylococcus epidermidis, different skin models, and in vivo on adult and young volunteers. Results In vitro, the complex modulated bacterial biofilm formation and growth, decreased the cytokines [interleukin (IL)-1, IL-6, IL-4] and neuropeptides (SP) release, and increased the expression of CL1 and CL4. On volunteers with dry skin, the complex had a moisturizing effect after 1 h of application. Dryness and roughness were also reduced in young subjects with atopic skin. The balm decreased erythema and pruritus after 21 days of topical application on 60 young subjects. On 22 adult subjects the stinging score was decreased after application. Conclusions The Active Oligo Skin complex™ appears to display potent antipruritic and anti-inflammatory activities both in vitro and in vivo.