Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease that has a heavy social and economic impact on all societies and for which there is still no cure. Multitarget-directed ligands (MTDLs) seem to be a promising therapeutic strategy for finding an effective treatment for this disea...

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Published inInternational journal of molecular sciences Vol. 24; no. 11
Main Authors Dakhlaoui, Imen, Bernard, Paul, Pietrzak, Diana, Simakov, Alexey, Maj, Maciej, Refouvelet, Bernard, Béduneau, Arnaud, Cornu, Raphaël, Jozwiak, Krzysztof, Chabchoub, Fakher, Iriepa, Isabel, Martin, Helene, Marco-Contelles, José, Ismaili, Lhassane
Format Journal Article
LanguageEnglish
Published MDPI 04.06.2023
Subjects
Chemical Sciences
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Summary:Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease that has a heavy social and economic impact on all societies and for which there is still no cure. Multitarget-directed ligands (MTDLs) seem to be a promising therapeutic strategy for finding an effective treatment for this disease. For this purpose, new MTDLs were designed and synthesized in three steps by simple and cost-efficient procedures targeting calcium channel blockade, cholinesterase inhibition, and antioxidant activity. The biological and physicochemical results collected in this study allowed us the identification two sulfonamide-dihydropyridine hybrids showing simultaneous cholinesterase inhibition, calcium channel blockade, antioxidant capacity and Nrf2-ARE activating effect, that deserve to be further investigated for AD therapy.
ISSN:1422-0067
1661-6596
DOI:10.3390/ijms24119742