Echecs thérapeutiques multiples et successifs chez un patient infecté par Plasmodium falciparum au Cambodge et traité par dihydroartémisinine-pipéraquine

Cases of treatment failures following administration of artemisinin-based combination therapies (ACT) remain rare in malaria endemic areas. In Cambodia, however, failures of these treatments are now commonly observed. Usually, these post-treatment recurrences occur only once and a second course of t...

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Published inBulletin de la Société de pathologie exotique Vol. 109; no. 2; pp. 87 - 90
Main Authors Witkowski, B., Khim, N., Kim, S., Domergue, A., Duru, V., Menard, D.
Format Journal Article
LanguageFrench
Published Masson 01.05.2016
Subjects
Antimalarials
Artemisinins
Cambodia
Drug Therapy, Combination
Human health and pathology
Humans
Infectious diseases
Life Sciences
Malaria, Falciparum
Male
Middle Aged
Plasmodium falciparum
Quinolines
Recurrence
Treatment Failure
South East Asia
Plasmodium falciparum
Kachaun
ACT
Ratanakiri
Malaria
Cambodia
Chemoresistance
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Summary:Cases of treatment failures following administration of artemisinin-based combination therapies (ACT) remain rare in malaria endemic areas. In Cambodia, however, failures of these treatments are now commonly observed. Usually, these post-treatment recurrences occur only once and a second course of the same treatment is sufficient to cure patients.We describe here an atypical case of a Plasmodium falciparum-infected patient manifesting several malaria recrudescence episodes following dihydroartemisinin-piperaquine (Eurartesim®) treatment. This case report illustrates the current issue of resistance to the latest generation of antimalarial drugs in Southeast Asia and highlights the difficulty in efficaciously fighting malaria in this region if new therapy remains unimplemented.
ISSN:0037-9085
1961-9049
DOI:10.1007/s13149-016-0487-4