Poly(adp-ribose) Polymerase-1 Regulates Tracp Gene Promoter Activity During RANKL-Induced Osteoclastogenesis

The Tracp gene encodes an acid phosphatase strongly upregulated during osteoclastogenesis on RANKL treatment. Using the mouse osteoclastic model RAW264.7, we studied Tracp gene expression, and we identified PARP-1 as a transcriptional repressor negatively regulated by RANKL during osteoclastogenesis...

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Bibliographic Details
Published inJournal of bone and mineral research Vol. 23; no. 4; pp. 564 - 571
Main Authors Beranger, Guillaume E., Momier, David, Rochet, Nathalie, Carle, Georges F., Scimeca, Jean-Claude
Format Journal Article
LanguageEnglish
Published American Society for Bone and Mineral Research 01.04.2008
Subjects
Acid Phosphatase
Animals
Biochemistry
Biochemistry, Molecular Biology
Bioengineering
Biomaterials
Cancer
Cell Behavior
Cell Line
Cellular Biology
Electrophoretic Mobility Shift Assay
Gene Expression Regulation, Enzymologic
Genomics
Human health and pathology
Isoenzymes
Life Sciences
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Molecular biology
Osteoclasts
Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases
Promoter Regions, Genetic
RANK Ligand
Rhumatology and musculoskeletal system
RNA, Messenger
RNA, Small Interfering
Tartrate-Resistant Acid Phosphatase
Transcription, Genetic
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Summary:The Tracp gene encodes an acid phosphatase strongly upregulated during osteoclastogenesis on RANKL treatment. Using the mouse osteoclastic model RAW264.7, we studied Tracp gene expression, and we identified PARP-1 as a transcriptional repressor negatively regulated by RANKL during osteoclastogenesis.
ISSN:0884-0431
1523-4681
DOI:10.1359/jbmr.071111