and placental inflammation in early preterm delivery

may infect the placenta and subsequently lead to preterm delivery. Our aim was to evaluate the relationship between the presence of and signs of placental inflammation in women who delivered at 32 weeks gestation or less. Setting: placental histology and clinical data were prospectively obtained fro...

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Bibliographic Details
Published inEuropean journal of epidemiology Vol. 26; no. 5; pp. 421 - 428
Main Authors Rours, G. Ingrid J. G., Krijger, Ronald R., Ott, Alewijn, Willemse, Hendrina F. M., Groot, Ronald, Zimmermann, Luc J. I., Kornelisse, Renee F., Verbrugh, Henri A., Verkooijen, Roel P.
Format Journal Article
LanguageEnglish
Published Springer Verlag 24.03.2011
Subjects
Life Sciences
Santé publique et épidémiologie
Pregnancy
Prematurity
Placental inflammation
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Summary:may infect the placenta and subsequently lead to preterm delivery. Our aim was to evaluate the relationship between the presence of and signs of placental inflammation in women who delivered at 32 weeks gestation or less. Setting: placental histology and clinical data were prospectively obtained from 304 women and newborns at the Erasmus MC-Sophia, Rotterdam, the Netherlands. testing of placentas was done retrospectively using PCR. was detected in 76 (25%) placentas. Histological evidence of placental inflammation was present in 123 (40%) placentas: in 41/76 (54%) placentas with versus 82/228 (36%) placentas without infection (OR 2.1, 95% CI 1.2-3.5). infection correlated with the progression ( = 0.009) and intensity ( = 0.007) of materno-fetal placental inflammation. DNA was frequently detected in the placenta of women with early preterm delivery, and was associated with histopathological signs of placental inflammation.
ISSN:0393-2990
1573-7284
DOI:10.1007/s10654-011-9569-2