Functional dyspepsia impares quality of life in the adult population

• Published in: Alimentary pharmacology & therapeutics Vol. 33; no. 11
• Main Authors: Aro, Pertti, Talley, Nicholas J, Agreus, Lars, Johansson, Sven-Erik, Bolling-Sternevald, Elisabeth, Storskrubb, Tom, Ronkainen, Jukka
• Format: Journal Article
• Language: English
• Published: Wiley 28.03.2011
• Subjects: Medicine
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/j.1365-2036.2011.04640.x

Background: Data on the impact of functional dyspepsia on health related quality of life in the general adult population are scarce. Aim: To explored the impact of functional dyspepsia applying the Rome III definition on health related quality of life in the general population. Method: A random sample of an adult Swedish population (n=1,001, The Kalixanda study) was invited to undergo an oesophagogastroduodenoscopy. An extended abdominal symptom questionnaire and Short Form 36 (SF-36) questionnaire, which includes eight domains measuring physical, mental and social aspects of quality of life, were completed at the clinic visit just before oesophagogastroduodenoscopy. Results: 202 (20.2%) individuals reported uninvestigated dyspepsia (UID), 157 (15.7%) functional dyspepsia (FD), 52 (5.2%) epigastric pain syndrome (EPS) and 122 (12.2%) postprandial distress syndrome (PDS). UID, FD and PDS had a clinically meaningful (a ≥5 point) and statistically significant impact (p<0.05) on health related quality of life in all SF-36 domains except for Role Emotional. EPS had a significant impact on Bodily Pain and Vitality. Overlap of FD with irritable bowel syndrome (IBS) had a significant impact on Bodily Pain (p=0.002) and General Health (p=0.02) while FD overlap with gastro-oesophageal reflux symptoms (GORS) had a significant impact on Bodily Pain (p=0.02) compared with FD without any overlap with IBS or GORS. Conclusions: Functional dyspepsia impacts all main domains describing physical, mental and social aspects of health related quality of life in the general population. Overlap of FD with IBS or GORS impacts the domain related to bodily pain.