Alternative models for QTL detection in livestock. III. Heteroskedastic model and models corresponding to several distributions of the QTL effect

This paper describes two kinds of alternative models for QTL detection in livestock: an heteroskedastic model, and models corresponding to several hypotheses concerning the distribution of the QTL substitution effect among the sires: a fixed and limited number of alleles or an infinite number of all...

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Bibliographic Details
Published inGenetics selection evolution (Paris) Vol. 31; no. 4; pp. 341 - 350
Main Authors Goffinet, Bruno B., Le Roy, Pascale P., Boichard, Didier, Elsen, Jean Michel J. M., Mangin, Brigitte B.
Format Journal Article
LanguageEnglish
Published BioMed Central 1999
Subjects
HETEROSKEDASTIC MODEL
HALF-SIB FAMILIES
LINKAGE DISEQUILIBRIUM
QTL DETECTION
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Summary:This paper describes two kinds of alternative models for QTL detection in livestock: an heteroskedastic model, and models corresponding to several hypotheses concerning the distribution of the QTL substitution effect among the sires: a fixed and limited number of alleles or an infinite number of alleles. The power of different tests built with these hypotheses were computed under different situations. The genetic variance associated with the QTL was shown in some situations. The results showed small power differences between the different models, but important differences in the quality of the estimations. In addition, a model was built in a simplified situation to investigate the gain in using possible linkage disequilibrium.
ISSN:0999-193X
1297-9686