The M3C Process: A New Multicolumn Chromatographic Process Integrating a Concentration Step. IThe Equilibrium Model

A new Multicolumn Chromatographic process, called M3C, is introduced. The originality of this process relies on the integration of a concentration loop at the extract level on the recycling stream of a Multicolumn Continuous Process (Simulated Moving Bed, Varicol). Thanks to the tools of the equilib...

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Bibliographic Details
Published inSeparation science and technology Vol. 41; no. Issue 121; pp. 2639 - 2663
Main Authors Abdelmoumen, S., Muhr, L., Bailly, M., Ludemann-Hombourger, O.
Format Journal Article
LanguageEnglish
Published Taylor & Francis 2006
Subjects
Chemical and Process Engineering
Engineering Sciences
Multicolumn continuous chromatography
equilibrium theory
preparative chromatography
M3C process
displacement effect
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Summary:A new Multicolumn Chromatographic process, called M3C, is introduced. The originality of this process relies on the integration of a concentration loop at the extract level on the recycling stream of a Multicolumn Continuous Process (Simulated Moving Bed, Varicol). Thanks to the tools of the equilibrium theory applied to an equivalent True Moving Bed integrating a concentration step, the working parameters of this new process are estimated in the case of multicomponent competitive Langmuir adsorption isotherms. The performances of this process are compared to those of the classical True Moving Bed in terms of productivity and eluent consumption, and exhibit significant improvement.
ISSN:0149-6395
1520-5754
DOI:10.1080/01496390600829992