Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians

We have carried out a detailed reexamination of the genetics of the APM1 locus and its contribution to the genetic basis of type 2 diabetes susceptibility in the French Caucasian population. The G allele of single nucleotide polymorphism -11426 in the APM1 promoter showed modest association with typ...

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Bibliographic Details
Published inDiabetes (New York, N.Y.) Vol. 53; no. 11; pp. 2977 - 83
Main Authors Gibson, Fernando, Froguel, Philippe
Format Journal Article
LanguageEnglish
Published American Diabetes Association 01.11.2004
Subjects
Adiponectin
Chromosome Mapping
Diabetes Mellitus, Type 2
European Continental Ancestry Group
France
Genetic Predisposition to Disease
Genetics
Human genetics
Humans
Intercellular Signaling Peptides and Proteins
Life Sciences
Polymorphism, Single Nucleotide
Promoter Regions (Genetics)
Risk Factors
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Summary:We have carried out a detailed reexamination of the genetics of the APM1 locus and its contribution to the genetic basis of type 2 diabetes susceptibility in the French Caucasian population. The G allele of single nucleotide polymorphism -11426 in the APM1 promoter showed modest association with type 2 diabetes (odds ratio 1.44 [95% CI 1.04-1.98]; P = 0.03), providing corroborative evidence that single nucleotide polymorphisms in the APM1 promoter region contribute to the genetic risk of type 2 diabetes. A "sliding window" analysis identified haplotypes 1-1-1, 1-1-1-1, and 1-1-1-1-1 as being strongly protective against type 2 diabetes (P
ISSN:0012-1797
1939-327X