Differences in HIV Markers between Infected Individuals Treated with Different ART Regimens: Implications for the Persistence of Viral Reservoirs

In adherent individuals, antiretroviral therapy (ART) suppresses HIV replication, restores immune function, and prevents the development of AIDS. However, ART is not curative and has to be followed lifelong. Persistence of viral reservoirs forms the major obstacle to an HIV cure. HIV latent reservoi...

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Bibliographic Details
Published inViruses Vol. 12; no. 5
Main Authors Darcis, Gilles, Berkhout, Ben, Pasternak, Alexander O
Format Journal Article
LanguageEnglish
Published MDPI AG 01.05.2020
Subjects
Antiretroviral agents
Biological markers
Dosage and administration
Drug therapy
Health aspects
HIV infections
Netherlands
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Summary:In adherent individuals, antiretroviral therapy (ART) suppresses HIV replication, restores immune function, and prevents the development of AIDS. However, ART is not curative and has to be followed lifelong. Persistence of viral reservoirs forms the major obstacle to an HIV cure. HIV latent reservoirs persist primarily by cell longevity and proliferation, but replenishment by residual virus replication despite ART has been proposed as another potential mechanism of HIV persistence. It is a matter of debate whether different ART regimens are equally potent in suppressing HIV replication. Here, we summarized the current knowledge on the role of ART regimens in HIV persistence, focusing on differences in residual plasma viremia and other virological markers of the HIV reservoir between infected individuals treated with combination ART composed of different antiretroviral drug classes.
ISSN:1999-4915
1999-4915
DOI:10.330/v100