Metabolism of creatine is amended due to the way is administered/O metabolismo de creatina e alterado devido ao modo como e administrada

• Published in: Revista brasileira de nutrição esportiva Vol. 6; no. 34; p. 315
• Main Authors: de Araujo, Michel Barbosa, de Moura, Leandro Pereira, Vieira, Jr., Roberto Carlos, Costa, Jr., Marcelo, Dalia, Rodrigo Augusto, Sponton, Amanda Christine da Silva, de Mello, Maria Alice Rostom
• Format: Journal Article
• Language: Portuguese
• Published: Instituto Brasileiro de Pesquisa e Ensino em Fisiologia do Exercicio. IBPEFEX 01.07.2012
• Subjects: Creatine; Dextrins; Exercise; Glucose metabolism; Glycogen; Physiological aspects
• ISSN: 1981-9927; 1981-9927

The study aims two different procedures for administration of creatine to laboratory rats. Wistar rats (90 days) were divided into three groups according to the mode of administration of creatine for four weeks: control group (C): rats that did not take creatine, creatine group gavage (G) rats that received creatine supplementation (0.107 g/kg body weight) by gavage and creatine group maltodextrin (M) rats supplemented with creatine (0.107 g/ kg body weight) with the addition of maltodextrin (0.160 g/kg body weight) by gavage. At the end of the experiment the body mass gain, area under the curve of food and water intake, rate of hydration of the gastrocnemius muscle, serum creatine concentration and hepatic glycogen concentration in liver and muscle (gastrocnemius and soleus) were evaluated. Weight gain, the area under the curve of food intake and hydration rate of muscle did not differ between groups. The area under the curve showed increased water intake for the animals of group M in the animals of group G. The concentration of creatine serum and muscle showed no differences, as well as liver glycogen levels and the gastrocnemius muscle, while for the soleus muscle there was an increase due to the creatine groups G and M. When the concentration of creatine in the liver was examined and observed an increase in this substrate. Thus, it could be concluded that the way is creatine administration may interfere with his metabolism.