4,5-dihydrooxazole

One-pot synthesis of (E)-5-[bromo(phenyl)methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole (9) from propargylic alcohol 5 and p-toluamide (6) was achieved via gold(III)-catalyzed propargylic substitution, followed by gold(III)-catalyzed bromocyclization. The structure of 9 was confirmed by an X-ray...

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Published inMolBank Vol. 2024; no. 1
Main Authors Morita, Nobuyoshi, Kurami, Saki, Ishii, Naho, Tanaka, Kosaku, Hashimoto, Yoshimitsu, Tamura, Osamu
Format Journal Article
LanguageEnglish
Published MDPI AG 01.02.2024
Subjects
Amides
Chemical tests and reagents
Organic compounds
Oxazoles
Synthesis
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Summary:One-pot synthesis of (E)-5-[bromo(phenyl)methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole (9) from propargylic alcohol 5 and p-toluamide (6) was achieved via gold(III)-catalyzed propargylic substitution, followed by gold(III)-catalyzed bromocyclization. The structure of 9 was confirmed by an X-ray crystallographic analysis.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1769