Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete IClitocybe clavipes/I with Cytotoxic Activity

Four new meroterpenoids, Clavilactone M-P, possessing novel aminoglycoside moiety (1–4) and a 10-membered carbocycle fused with an α,β-epoxy-γ-lactone, were isolated from Clitocybe clavipes, a basidiomycete. Their structures with absolute configurations were determined by extensive analysis of their...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 14
Main Authors Sun, Zhonghao, Ma, Yongben, Zhang, Jiawen, Ma, Guoxu, Wu, Haifeng, Shi, Leiling, Sun, Zhaocui, Xu, Xudong
Format Journal Article
LanguageEnglish
Published MDPI AG 01.07.2023
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China
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Summary:Four new meroterpenoids, Clavilactone M-P, possessing novel aminoglycoside moiety (1–4) and a 10-membered carbocycle fused with an α,β-epoxy-γ-lactone, were isolated from Clitocybe clavipes, a basidiomycete. Their structures with absolute configurations were determined by extensive analysis of their spectroscopic data, and the ECD method. All the isolated compounds (1–4) were evaluated for their antitumor activity against three human cancer cell lines using the MTT assay. Compound 1 and 2 exhibited a significant suppression of cell viability in the Hela (IC[sub.50] = 22.8 and 19.7 μM) cell line.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28145456