3--5-fluoro-1IH/I-pyrazole

In this work, the title compound was synthesized via the visible-light-induced radical denitrogenative trifluoromethylation of the corresponding vinyl azide followed by Cs[sub.2] CO[sub.3] -mediated defluorinative cyclization of the resultant azine. The widely available sodium trifluoromethanesulfin...

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Bibliographic Details
Published inMolBank Vol. 2023; no. 2
Main Authors Paveliev, Stanislav A, Ustyuzhanin, Alexander O, Krylov, Igor B, Terent’ev, Alexander O
Format Journal Article
LanguageEnglish
Published MDPI AG 01.04.2023
Subjects
Analysis
Chemical synthesis
Fluorine compounds
Heterocyclic compounds
Identification and classification
Infrared spectroscopy
Mass spectrometry
Methods
Nuclear magnetic resonance spectroscopy
Pyrazoles
Structure
Russia
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Summary:In this work, the title compound was synthesized via the visible-light-induced radical denitrogenative trifluoromethylation of the corresponding vinyl azide followed by Cs[sub.2] CO[sub.3] -mediated defluorinative cyclization of the resultant azine. The widely available sodium trifluoromethanesulfinate is used as a precursor of CF[sub.3] radicals, while graphitic carbon nitride (g-C[sub.3] N[sub.4] ) is employed as an environmentally friendly, cheap, and efficient heterogeneous photocatalyst. The structure of the synthesized compound was established by [sup.1] H, [sup.13] C, [sup.19] F-NMR, IR spectroscopy, and mass-spectrometry.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1620