Basic study of less invasive high-intensity focused ultrasound sequence

• Published in: Journal of medical ultrasonics (2001) Vol. 43; no. 4; p. 487
• Main Authors: Ichizuka, Kiyotake, Matsuoka, Ryu, Aoki, Hiroko, Hasegawa, Junichi, Okai, Takashi, Umemura, Shin-ichiro
• Format: Journal Article
• Language: English
• Published: Springer 01.10.2016
• ISSN: 1346-4523
• DOI: 10.1007/s10396-016-0725-x

Purpose The objective of the present study was to develop a high-intensity focused ultrasound (HIFU) transducer more suitable for clinical use in fetal therapy for twin reversed arterial perfusion (TRAP) sequence. Materials and methods We created a cooling and degassed water-circulating-type HIFU treatment device. HIFU was applied to renal branch vessels in three rabbits. Sequential HIFU irradiation contains a trigger wave, heating wave, and rest time. The duration of HIFU application was 10 s/course. Targeting could be achieved by setting the imaging probe in the center and placing the HIFU beam and imaging ultrasonic wave on the same axis. Result We confirmed under sequential HIFU irradiation with a total intensity of 1.94 kW/cm.sup.2 (spatial average temporal average intensity) that the vein and artery were occluded in all three rabbits. Conclusion Simultaneous occluding of the veins and arteries was confirmed with trigger waves and a resting phase using the HIFU transducer treatment device created for this study. Clinical application appears possible and may represent a promising option for fetal therapy involving TRAP sequence.