Chelator-free radiolabeling of dextran with .sup.68Ga for PET studies
The possibility of .sup.68Ga-dextran complex formation was analyzed in an HEPES-buffered (pH = 4.5) as well as in an alkaline (pH = 9) solution. The result outlined that the alkaline solution was more efficient to achieve a radiolabeling efficiency of 99% for a 5 mg ml.sup.-1 dextran solution (10 mi...
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Published in | Journal of radioanalytical and nuclear chemistry Vol. 311; no. 3; p. 1811 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Springer
01.03.2017
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Subjects | |
Online Access | Get full text |
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Summary: | The possibility of .sup.68Ga-dextran complex formation was analyzed in an HEPES-buffered (pH = 4.5) as well as in an alkaline (pH = 9) solution. The result outlined that the alkaline solution was more efficient to achieve a radiolabeling efficiency of 99% for a 5 mg ml.sup.-1 dextran solution (10 min, 90 °C). .sup.68Ga-dextran was stable 88, 71 and 86% after 2 h at storage and toward cysteine solution and human serum, respectively. The highest ROI derived %ID g.sup.-1 was found within the lungs, followed by the blood, liver, and bladder. Furthermore, a significant uptake was observed in the cartilage tissue. .sup.68Ga-dextran excreted more by the urinary and less by the biliary pathways. |
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ISSN: | 0236-5731 1588-2780 |
DOI: | 10.1007/s10967-016-5164-z |