Characterization and qualification of diclofenac sodium as a secondary standard/Caracterizacao e qualificacao de diclofenaco de sodio como padrao secundario
This paper aimed to characterize and qualify a secondary standard of diclofenac sodium as a reference standard in the quality control of medicines. The identity of the candidate was confirmed through infrared spectroscopy and the content (99.63%) determined by high performance liquid chromatography...
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Published in | Acta scientiarum. Technology Vol. 34; no. 1; p. 89 |
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Main Authors | , , , , |
Format | Journal Article |
Language | Spanish |
Published |
Universidade Estadual de Maringa
01.01.2012
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Online Access | Get full text |
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Summary: | This paper aimed to characterize and qualify a secondary standard of diclofenac sodium as a reference standard in the quality control of medicines. The identity of the candidate was confirmed through infrared spectroscopy and the content (99.63%) determined by high performance liquid chromatography (HPLC) by comparing with the compendial primary standard. The quality of the secondary standard was also supported by redox titration in non-aqueous media, related substances and UV spectrum by HPLC. Keywords: infrared spectroscopy, reference standard, HPLC. O objetivo deste artigo e caracterizar e qualificar um padrao secundario de diclofenaco de sodio como padrao de referencia no controle de qualidade de medicamentos. A identidade do candidato foi confirmada por espectroscopia na regiao do infravermelho e sua pureza (99,63%) determinada por cromatografia liquida de alta eficiencia (CLAE) por comparacao com padrao primario. A qualidade do padrao secundario tambem foi suportada por titulacao redox em meio nao-aquoso, espectroscopia na regiao do UV-visivel. Palavras-chave: espectroscopia de infravermelho, padrao de referencia, CLAE. |
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ISSN: | 1806-2563 |
DOI: | 10.4025/actascitechnol.v34i1.11654 |