Adverse effects of ranitidine applied in therapeutic dosage in healthy dogs/Efeitos colaterais da ranitidina aplicada em dose terapeutica em caes saudaveis

• Published in: Ciência rural Vol. 40; no. 2; p. 356
• Main Authors: Cavalcanti, Guilherme Albuquerque de Oliveira, Feliciano, Marcus Antonio Rossi, Silveira, Tatiana, Leite, Carlos Artur Lopes, Araujo, Roberto Baracat
• Format: Journal Article
• Language: Spanish
• Published: Universidade Federal de Santa Maria 01.02.2010
• Subjects: Analysis; Complications and side effects; Dogs; Ranitidine
• ISSN: 0103-8478; 1678-4596

The purpose of this study was to verify if the ranitidine dosage of 2mg [kg.sup.-1] by intravenous path causes emesis or hypotension in healthy dogs. They were selected 10 Labrador Retriever, 10 Beagles and 10 mongrel dogs, five animals of each sex. The animals were submitted to clinical examination and blood pressure evaluation before ranitidine administration and also 10 minutes and 4 hours after administration of it. After administration was observed that 13.3% of the animals presented normal; 6.7% of the dogs presented apathy; 50% of the animals presented salivation and 30% presented apathy, salivation, emesis mimic or emesis. There was no significative arterial blood pressure decrease after ranitidine administration. It was concluded that ranitidine useful in therapeutic dosage by intravenous path may provoke apathy, salivation, emesis mimic and emesis. Key words: ranitidine, canines, undesired effects, emesis. O objetivo deste trabalho foi verificar se a dose de ranitidina 2mg [kg.sup.-1], aplicada via intravenosa, causa emese ou hipotensao em caes saudaveis. Foram selecionados 10 caes da raca Retriever do Labrador, 10 da raca Beagle e 10 caes sem raca definida, sendo cinco animais de cada sexo. Os animais foram submetidos ao exame clinico e a avaliacao da pressao sanguinea antes da aplicacao do farmaco e tambem 10 minutos e quatro horas apos a administracao deste. Apos a aplicacao, observou-se que 13,3% dos animais apresentaramse normais; 6,7% dos caes apresentaram apatia; 50% dos animais apresentaram salivacao e 30% apresentaram apatia, salivacao, mimica de vomito ou emese. Nao houve diminuicao significativa da pressao arterial apos a administracao do farmaco. Conclui-se que o uso de ranitidina na dose terapeutica, aplicada via intravenosa, pode provocar apatia, salivacao, mimica de vomito e emese. Palavras-chave: ranitidina, caninos, efeitos indesejados, vomito.