Cardiorespiratory and metabolic answer with microemulsion and lipid emulsion of propofol in cats/Respostas cardiorrespiratoria e metabolica do propofol nas formulacoes em emulsao lipidica ou microemulsao em gatas

• Published in: Ciência rural Vol. 43; no. 8; p. 1435
• Main Authors: Tamanho, Renato Batista, Correa, Andre Luis, de Moraes, Aury Nunes, Beier, Suzane Lilian, Regalin, Doughlas, Farias, Felipe Hertzing, Oleskovicz, Nilson
• Format: Journal Article
• Language: Spanish
• Published: Universidade Federal de Santa Maria 01.08.2013
• Subjects: Analysis; Phenols
• ISSN: 0103-8478; 1678-4596

The aim of the present study was to evaluate the cardiorespiratory and metabolic effects from lipid emulsion and microemulsion of propofol in cats. Twelve healthy adult cats were included, and divided into two groups: microemulsion group (MICRO, n=6) and lipid emulsion (EMU, n=6), where they received propofol in the respective formulation, in a dose sufficient for intubation. The animals were then intubated and provided with 100% oxygen through a non-rebreathing circuit. Immediately after, the infusion of propofol was initiated (0.3mg [kg.sup.-1] [min.sup.-1]) and maintained for 90 minutes. The dose required for induction was 9.5 ± 1.3mg [kg.sup.-1] and 10 ± 1mg [kg.sup.-1] in MICRO and EMU, respectively. The SAP, MAP, DAP and pH values were lower in all moments in EMU when compared to MICRO; the RR in EMU was lower from T30 to T75 in comparison to MICRO. The paC[O.sub.2] was greater in the EMU from T15 to T90. The times to extubation, sternal recumbency, ambulation and total recovery were 40.6 ± 30.7, 91 ± 37.5, 134.5 ± 54.5 and 169.1 ± 55.4 minutes in MICRO and 68.8 ± 37.3, 133.3 ± 85.3, 171.3 ± 77.1 and 233.1 [+ or -] 60.6 minutes in EMU, respectively. There was an increase of the enzyme alanine aminotransferase from 12 to 72 hours in EMU and in MICRO from 48 to 72 hours. The propofol in microemulsion presents clinical characteristics of induction and maintenance, and metabolic effects similar to the formulation in lipid emulsion. The microemulsion formulation provides a better cardiovascular and respiratory stability for induction and continuous infusion in healthy cats. Key words: propofol, microemulsion, lipid emulsion, cats. O presente estudo objetiva avaliar os efeitos cardiorrespiratorios e metabolicos do propofol em emulsao lipidica e microemulsao em gatas. Foram utilizadas 12 gatas, higidas, adultas, alocadas em dois grupos: microemulsao (MICRO, n=6) e emulsao lipidica (EMU, n=6), os quais receberam propofol, na respectiva formulacao, em dose suficiente para intubacao. Em seguida, foram intubados, fornecendo-se oxigenio 100%, em sistema sem reinalacao de gases. Ato continuo, iniciou-se a infusao de propofol na dose de 0,3mg [kg.sup.-1] [min.sup.-1] durante 90 minutos. A dose necessaria para inducao foi de 9,5 [+ or -] 1,3mg [kg.sup.-1] e 10 ± 1mg [kg.sup.-1] para MICRO e EMU, respectivamente. Os valores de pressao arterial sistolica (PAS), pressao arterial media (PAM), pressao arterial diastolica (PAD) e pH foram menores, em todos os momentos, no EMU em relacao ao MICRO; a f do EMU foi menor de T30 ate T75 em relacao ao MICRO. A PaC[O.sub.2] do EMU foi maior de T15 ate T90. Os tempos de extubacao, decubito esternal, deambulacao e recuperacao total foram de 40,6 ± 30,7; 91 ± 37,5; 134,5 ± 54,5 e 169,1 [+ or -] 55,4 minutos no MICRO e de 68,8 ± 37,3; 133,3 ± 85,3; 171,3 ± 77,1 e 233,1 ± 60,6 minutos no EMU, respectivamente. Houve aumento da enzima Alanina Aminotransferase de 12 as 72h no EMU e de 48 as 72h no MICRO. O propofol em microemulsao apresentou caracteristicas clinicas de inducao e manutencao, bem como efeitos metabolicos semelhantes a formulacao em emulsao lipidica. A formulacao em microemulsao proporcionou maior estabilidade cardiovascular e respiratoria para inducao e infusao continua em gatas higidas. Palavras-chave: propofol, microemulsao, emulsao lipidica, gatas.