Synthesis and antimicrobial activity of quaternized heterocyclic systems based on [alpha]-pyridoin and 2,2'-pyridyl

A series of uni- and biquaternized derivatives of [alpha]-pyridoin and 2, 2'-pyridyl were synthesized. Their antimicrobial activity (AMA) was studied with respect to Gram-negative (E. coli) and Gram-positive (S. aureus) bacterial strains. It was established that the AMA depended on the nature o...

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Published inPharmaceutical chemistry journal Vol. 46; no. 6; p. 346
Main Authors El'chishcheva, N.V, Shklyaev, Yu. V, Vnutskikh, Zh. A, Chekryshkin, Yu. S, Odegova, T.F
Format Journal Article
LanguageEnglish
Published Springer 01.09.2012
Subjects
Pyridine
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Summary:A series of uni- and biquaternized derivatives of [alpha]-pyridoin and 2, 2'-pyridyl were synthesized. Their antimicrobial activity (AMA) was studied with respect to Gram-negative (E. coli) and Gram-positive (S. aureus) bacterial strains. It was established that the AMA depended on the nature of the radical and the presence of an oxygen between the pyridyl rings. The maximum activity was observed for 2, 3-bis-(Ar-dodecylpyridirtium-2'-yl)quinoxaline dibromide. Keywords: quaternization, antimicrobial activity, [alpha]-pyridoin, 2,2'-pyridyl, quinoxaline.
ISSN:0091-150X
1573-9031