Synthesis and antimicrobial activity of 5-aryl-4-acyl -3-pyrrolin-2-ones

A series of 5-aryl-4-acyl(heteroyl)-3-hydroxy-1-(3-ethoxypropyl)-3-pyrrolin-2- ones were synthesized using the reaction of 3-ethoxypropylamine with a mixture of aromatic aldehyde and methyl esters of acyl(heteroyl)-pyruvic acid. The antimicrobial activity of the synthesized compounds was studied. Ke...

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Published inPharmaceutical chemistry journal Vol. 46; no. 1; p. 23
Main Authors Gem, V.L, Bobyleva, A.A, Levandovskaya, E.B, Odegova, T.F, Vakhrin, M.I
Format Journal Article
LanguageEnglish
Published Springer 01.04.2012
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Summary:A series of 5-aryl-4-acyl(heteroyl)-3-hydroxy-1-(3-ethoxypropyl)-3-pyrrolin-2- ones were synthesized using the reaction of 3-ethoxypropylamine with a mixture of aromatic aldehyde and methyl esters of acyl(heteroyl)-pyruvic acid. The antimicrobial activity of the synthesized compounds was studied. Key words: 5-aryl-4-acyl(heteroyl)-3-hydroxy-1-(3-ethoxypropyl)-3-pyrrolin-2- ones, synthesis, antimicrobial activity.
ISSN:0091-150X
1573-9031