A systematic review of hepatitis B virus

International sustainable development goals for the elimination of viral hepatitis as a public health problem by 2030 highlight the pressing need to optimize strategies for prevention, diagnosis and treatment. Selected or transmitted resistance associated mutations (RAMs) and vaccine escape mutation...

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Bibliographic Details
Published inPLoS neglected tropical diseases Vol. 12; no. 8
Main Authors Geretti, Anna-Maria, Mokaya, Jolynne, McNaughton, Anna L, Hadley, Martin J, Beloukas, Apostolos, Goedhals, Dominique, Matthews, Philippa C
Format Journal Article
LanguageEnglish
Published Public Library of Science 06.08.2018
Subjects
Development and progression
Drug resistance
Drug therapy
Gene mutation
Genetic aspects
Health aspects
Hepatitis B
Africa
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Summary:International sustainable development goals for the elimination of viral hepatitis as a public health problem by 2030 highlight the pressing need to optimize strategies for prevention, diagnosis and treatment. Selected or transmitted resistance associated mutations (RAMs) and vaccine escape mutations (VEMs) in hepatitis B virus (HBV) may reduce the success of existing treatment and prevention strategies. These issues are particularly pertinent for many settings in Africa where there is high HBV prevalence and co-endemic HIV infection, but lack of robust epidemiological data and limited education, diagnostics and clinical care. The prevalence, distribution and impact of RAMs and VEMs in these populations are neglected in the current literature. We therefore set out to assimilate data for sub-Saharan Africa through a systematic literature review and analysis of published sequence data, and present these in an on-line database (
ISSN:1935-2727