Successful tandem
Although autologous tandem hematopoietic SCT has improved the prognosis of patients with advanced high-risk neuroblastoma, the results remain unsatisfactory. In an attempt to induce the graft-versus-tumor effect, we performed autologous PBSCT followed by allogeneic cord blood transplantation in thre...
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Published in | Bone marrow transplantation (Basingstoke) Vol. 46; no. 6; p. 835 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Nature Publishing Group
01.06.2011
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Subjects | |
Online Access | Get full text |
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Summary: | Although autologous tandem hematopoietic SCT has improved the prognosis of patients with advanced high-risk neuroblastoma, the results remain unsatisfactory. In an attempt to induce the graft-versus-tumor effect, we performed autologous PBSCT followed by allogeneic cord blood transplantation in three consecutive advanced neuroblastoma cases with marked BM infiltration and high MYCN amplification. Severe acute complications did not occur in any patient and they have maintained disease-free survival for 37-60 months. This strategy appears to be feasible and effective for the treatment of extremely high-risk neuroblastoma cases. Bone Marrow Transplantation (2011) 46, 835-839; doi: 10.1038/bmt.2010.191; published online 9 August 2010 Keywords: neuroblastoma; MYCN amplification; cord blood transplantation; tandem transplantation |
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ISSN: | 0268-3369 |