Successful tandem

Although autologous tandem hematopoietic SCT has improved the prognosis of patients with advanced high-risk neuroblastoma, the results remain unsatisfactory. In an attempt to induce the graft-versus-tumor effect, we performed autologous PBSCT followed by allogeneic cord blood transplantation in thre...

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Bibliographic Details
Published inBone marrow transplantation (Basingstoke) Vol. 46; no. 6; p. 835
Main Authors Hirose, K, Goi, K, Koshizuka, K, Sugita, K, Akahane, K, Honna, H, Hasuda, N, Inukai, T, Takano, K, Kuroda, I
Format Journal Article
LanguageEnglish
Published Nature Publishing Group 01.06.2011
Subjects
Care and treatment
Genetic aspects
Neuroblastoma
Oncogenes
Physiological aspects
Stem cells
Transplantation
Japan
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Summary:Although autologous tandem hematopoietic SCT has improved the prognosis of patients with advanced high-risk neuroblastoma, the results remain unsatisfactory. In an attempt to induce the graft-versus-tumor effect, we performed autologous PBSCT followed by allogeneic cord blood transplantation in three consecutive advanced neuroblastoma cases with marked BM infiltration and high MYCN amplification. Severe acute complications did not occur in any patient and they have maintained disease-free survival for 37-60 months. This strategy appears to be feasible and effective for the treatment of extremely high-risk neuroblastoma cases. Bone Marrow Transplantation (2011) 46, 835-839; doi: 10.1038/bmt.2010.191; published online 9 August 2010 Keywords: neuroblastoma; MYCN amplification; cord blood transplantation; tandem transplantation
ISSN:0268-3369