Hepatic adiponectin receptors

Objective: Adiponectin signalling attenuates insulin resistance (IR) and steatosis hepatis in animal models. As adiponectin receptor (ADIPOR)1 and ADIPOR2 are critical components in the adiponectin signalling cascade, we studied hepatic ADIPOR1/2mRNA levels in humans and their relation to IR. Design...

Full description

Saved in:
Bibliographic Details
Published inInternational Journal of Obesity Vol. 34; no. 5; p. 846
Main Authors Felder, T.K, Patsch, W, Soyal, S.M, Hoffinger, H, Miller, K, Oberkofler, H, Krempler, F, Hahne, P
Format Journal Article
LanguageEnglish
Published Nature Publishing Group 01.05.2010
Subjects
Genetic aspects
Insulin resistance
Messenger RNA
Overweight persons
Physiological aspects
Risk factors
Austria
Online AccessGet full text

Cover

More Information
Summary:Objective: Adiponectin signalling attenuates insulin resistance (IR) and steatosis hepatis in animal models. As adiponectin receptor (ADIPOR)1 and ADIPOR2 are critical components in the adiponectin signalling cascade, we studied hepatic ADIPOR1/2mRNA levels in humans and their relation to IR. Design: We determined metabolic risk factors and levels of hepatic mRNA transcribed from ADIPOR1, ADIPOR2 and FOXO1 ,a putative up-stream regulator, in 43 and 34 obese subjects with low and high homeostasis model assessment-IR, respectively. Results: Plasma adiponectin and metabolic risk factors showed associations with IR as expected. Both hepatic ADIPOR1 and ADIPOR2 mRNA expression levels were higher in insulin-resistant subjects (P<0.0035). ADIPOR1 mRNA correlated with FOXO1 mRNA in obese insulin resistant (P = 0.0034), but not insulin-sensitive subjects, while no correlations of ADIPOR2 with FOXO1 mRNA were noted. FOXO1 enhanced transcription from the ADIPOR1 , but not the ADIPOR2 promoter in HepG2 cells. Conclusion: Increased hepatic ADIPOR1 and ADIPOR2 mRNA in insulin-resistant obese subjects may, at least in part, reflect a compensatory mechanism for reduced plasma adiponectin. FOXO1 may contribute to enhanced ADIPOR1 , but not ADIPOR2 transcription in IR. International Journal of Obesity (2010) 34, 846-851; doi: 10.1038/ijo.2010.7; published online 2 February 2010 Keywords: liver; insulin resistance; ADIPOR1; ADIPOR2; FOXO1
ISSN:0307-0565