Association between

has been demonstrated as a key risk factor for carbamazepine-induced severe cutaneous adverse reaction (sCAR), especially in Asian population. Oxcarbazepine (OXC) is a drug that has a similar structure of carbamazepine. However, the relationship between and induced cutaneous adverse reaction (cADR)...

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Bibliographic Details
Published inPharmacogenomics
Main Authors Liu, Yiwei, Yu, Yuncui, Nie, Xiaolu, Zhao, Libo, Wang, Xiaoling
Format Journal Article
LanguageEnglish
Published Future Medicine Ltd 01.04.2018
Subjects
cutaneous adverse reaction
oxcarbazepine
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Summary:has been demonstrated as a key risk factor for carbamazepine-induced severe cutaneous adverse reaction (sCAR), especially in Asian population. Oxcarbazepine (OXC) is a drug that has a similar structure of carbamazepine. However, the relationship between and induced cutaneous adverse reaction (cADR) remains unknown. This study aims to analyze this association in the published literature. After filtering studies, eight studies were finally included for meta-analysis, including 32 sCAR cases, 112 mild cutaneous adverse reaction (mcADR) cases, 281 OXC tolerant control and 946 population control cases. In the tolerant control group, an association was found between genotype and OXC-induced sCAR (odds ratio [OR]: 18.13; 95% CI: 6.77-48.56), but not in mcADR (OR: 1.43; 95% CI: 0.56-3.64). In population control group, an association was found between genotype and OXC-induced sCAR, (OR: 8.22; 95% CI: 3.03-22.34), but not in mcADR (OR: 2.06; 95% CI: 0.91-4.67). Our study demonstrates that the genetic risk factor may be a factor in OXC-induced sCAR.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2017-0189