Interethnic relationships of

To analyze the distribution of variants in two ethnically-related Mexican Native and Mestizo populations cohabitating the same econiche and their relationships with a distant Mestizo community. 314 volunteers were genotyped for gene variants ( , , , , , , , and ) using predesigned TaqMan probes. and...

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Published inPharmacogenomics Vol. 16; no. 7; pp. 703 - 712
Main Authors Perez-Paramo, Yadira Xitlalli, Hernandez-Cabrera, Francisco, Dorado, Pedro, Llerena, Adrian, Muñoz-Jimenez, Sergio, Ortiz-Lopez, Rocio, Rojas-Martinez, Augusto
Format Journal Article
LanguageEnglish
Published Future Medicine Ltd 01.05.2015
Subjects
Mestizo
Native American
PCA analysis
population pharmacogenetics
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Summary:To analyze the distribution of variants in two ethnically-related Mexican Native and Mestizo populations cohabitating the same econiche and their relationships with a distant Mestizo community. 314 volunteers were genotyped for gene variants ( , , , , , , , and ) using predesigned TaqMan probes. and wtxN were assessed by XL-PCR. , , and variants represented above 80.9% of total alleles. Chiapanecan communities showed low allele diversity compared with the northeastern population. Principal component analyses demonstrated clustering of both Mestizo populations. Variants associated to ultrarapid and poor metabolism were rare in Natives. Sharing of alleles in both Chiapanecan populations suggests an ongoing gene-flow. Original submitted 8 December 2014; Revision submitted 13 February 2015
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs.15.24